testosterone suspension half life

The synthetic anticholinesterase agents. Reversible cholinesterase blocking, leading to an accumulation of acetylcholine and enhancing effect on organs and tissues, and restore neuromuscular conduction. It causes slowing heart rate, increases the secretion of glands (salivary, bronchial, sweat and gastrointestinal tract (GIT)) and promotes the development of hypersalivation, bronhorei, gastric hyperacidity, constricts the pupil causes a spasm of accommodation, reduce intraocular pressure, increases the tone of smooth muscles of the intestine (peristalsis strengthens and relaxes the sphincter) and the bladder, causing a spasm of the bronchi, skeletal muscle toning.
Neostigmine is an antagonist antidepolyarizuyuschih curariform drugs. However, in large doses Neostigmine may itself cause a violation of neuromuscular conduction as a result of the accumulation of acetylcholine and resistant depolarization in the synapses.

It gives testosterone suspension half life direct H-nicotinic effects. The drugs are the same as the characteristic effects of cholinergic nerve excitation. In contrast, physostigmine largely stimulates muscles intestines, urinary bladder and uterus, little effect on the heart and does not cause central effects. When administered in therapeutic doses largely excited N-cholinergic receptors in skeletal muscle, increased neuromuscular transmission.

Indications
Myasthenia gravis, motor disorders after brain injury, paralysis, recovery period after suffering meningitis, polio, encephalitis, uterine inertia (rarely), open-angle glaucoma, optic atrophy, optic neuritis; atony of the gastrointestinal tract, bladder atony. Eliminating residual disorders of neuromuscular transmission of non-depolarizing muscle relaxants.
In pediatric practice: myasthenia gravis, motor disorders after brain injury, paralysis, recovery period after suffering meningitis, polio, encephalitis, optic atrophy, optic neuritis; atony of the gastrointestinal tract, bladder atony. Eliminating residual disorders of neuromuscular transmission of non-depolarizing muscle relaxants.

Contraindications:
Hypersensitivity, epilepsy, hyperkinesis, vagotomy, coronary artery disease, bradycardia, arrhythmia, angina, asthma, marked atherosclerosis, hyperthyroidism, peptic ulcer and 12 duodenal ulcer, peritonitis, mechanical obstruction of the gastrointestinal tract and urinary tract, prostate adenoma, period acute illness, intoxication in dramatically weakened children, pregnancy, lactation.

Precautions
Against anticholinergic drugs in children (in infants) against neomycin, streptomycin, kanamycin, etc. Antibiotics having antidepolyarizuyuschego effect of some local and general anesthetics, antiarrhythmic and several others. Medicaments violating cholinergic testosterone suspension half life transmission.

Dosing and Administration
Inside for 30 minutes before eating, adults – 10-15 mg 2-3 times a day, the maximum single dose of -15 mg daily – 50 mg. Children up to 10 years – 1 mg per 1 year of life per day, over 10 years – up to 10 mg / day (no more). The course of treatment (except for myasthenia gravis) – 25-30 days, if necessary – again in 3-4 weeks. Most of the total daily dose administered in the daytime when the patient is the most fatigue. With the weakness of labor activity – oral 3 mg 4-6 times a day at intervals of 40 minutes.

Side effects
Hypersalivation, spastic reduction and increased bowel motility, nausea, vomiting, bloating, diarrhea; headache, dizziness, weakness, loss of consciousness, drowsiness; cramps, blurred vision, arrhythmia, or bradi- tachycardia, atrioventricular block, block, nodal rhythm, non-specific changes in the electrocardiogram, heart failure, shortness of breath, respiratory depression up to the stop, bronchospasm, tremors, spasms and twitching of skeletal muscles, including muscle fasciculations language, seizures, dysarthria, artalgiya; frequent urination; profuse sweating; allergic reaction (facial flushing, rash, pruritus, anaphylaxis).

Overdose
Symptoms associated with overexcitation cholinergic receptors (cholinergic crisis): bradycardia, hypersalivation, cramps, bronchospasm, nausea, increased peristalsis, diarrhea, frequent urination, twitching of the muscles of the tongue and skeletal muscle, the gradual development of general weakness, decreased blood pressure (BP). Treatment: The dose reduce or stop treatment, atropine (1 ml of 0.1% solution) metacin anticholinergic drugs, etc., if necessary..

Interaction with other drugs
When myasthenia testosterone suspension half life administered in combination with aldosterone antagonists, glucocorticosteroids and anabolic hormones. Atropine, metacin et al. M-holinoblokatory weaken M-nicotinic effects (miosis, bradycardia, increased gastrointestinal motility, hypersalivation, etc.).