Combined preparation has antiglaucoma action. Proksodolol – non-selective beta-blocker, which also has a selective alpha-adrenoceptor blocking effect. It inhibits the production of aqueous humor. Pilocarpine – M-cholinomimetic, increases the outflow of intraocular fluid as a result of the disclosure of the anterior chamber angle and deblokady Schlemm’s canal. The testosterone suspension results drugs have an additive effect. The effect occurs within 1 hour after the installation reaches a maximum after 4-6 hours and lasts more than 24 hours. The drug does not have a damaging effect on eye tissues.
Indications for use :
- various forms of glaucoma (primary open, closure, congenital, Youth, secondary);
- lack of effectiveness of monotherapy proksodolola or pilocarpine.Contraindications :
- individual hypersensitivity to one of the components of the drug;
- bronchial asthma;
- broncho-obstructive pulmonary disease;
- chronic heart failure;
- hypotension testosterone suspension results;
- AV-block II-III degree;
- inflammation of the anterior part of the choroid (the iris, ciliary body);
- iritis, iridocyclitis.Dosage and administration :
Bury in the conjunctival cavity 1 drop 2 times a day.Side effects :
Burning, miosis, spasm of accommodation, tearing, transient blurred vision due to contraction of the pupil, eye pain, allergic conjunctivitis, skin dermatitis century. Headache, runny nose. Rarely observed bronchospasm, salivation and slowing the heart rate, lowering blood pressure.
Symptoms: nausea and bradycardia.
Treatment is symptomatic. Atropine can be used as a specific antidote. In severe bradycardia due parasympathomimetics overdose of atropine 0.5-2 mg administered parenterally.
Drug Interactions :
It goes well with beta-blockers and other drugs for the treatment of glaucoma.
In the event of an acute attack of angle-closure glaucoma, pilocarpine can be used alone or in combination with inhibitors of carbonic anhydrase.
Antagonists are atropine, pilocarpine, etc. M-anticholinergic agents.. M holinostimuliruyuschaya activity of pilocarpine is reduced by combination with tricyclic antidepressants, phenothiazines derivatives, hlorprotiksenom, clozapine; enhanced with anticholinesterase agents.
Perhaps the testosterone suspension results development of bradycardia and decreased blood pressure during general anesthesia with halothane.
Pregnancy and lactation :
Do not use during pregnancy and lactation, as no experience on the use of the drug during this period. Application proksokarpina possible if the expected therapeutic effect is greater than the risk of side effects.
Special instructions :
In the period of treatment is not recommended to wear soft contact lenses. If rigid lenses should remove them before digging in again and put in 15-20 minutes after instillation of the drug.
Patients who have lost chestkost after instillation of view, it is not recommended to drive a car or work with a complex technique that requires visual acuity immediately after instillation of the drug.
Treatment carried out at regular monitoring of intraocular pressure.